Name:
Stats: (2021 weeks 1 to 17)
| Rank | Name | G | SCK | FR | INT | DefTD | SpTmTD | PtAllw | YdAllw | FP/G | FantPt |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Indianapolis Colts IND | 16 | 32 | 14 | 19 | 1 | 0 | 21.2 | 345 | 6.5 | 104.0 |
| 2 | Arizona Cardinals ARI | 16 | 40 | 13 | 12 | 1 | 0 | 20.5 | 323 | 6.0 | 96.0 |
| 3 | Kansas City Chiefs KC | 16 | 30 | 13 | 15 | 3 | 0 | 21.3 | 369 | 6.5 | 104.0 |
| 4 | Buffalo Bills BUF | 16 | 33 | 11 | 19 | 1 | 0 | 17.4 | 287 | 6.2 | 99.0 |
| 5 | San Francisco 49ers SF | 16 | 43 | 11 | 7 | 2 | 0 | 21.3 | 313 | 5.7 | 91.0 |
| 6 | Tampa Bay Buccaneers TB | 16 | 45 | 11 | 16 | 2 | 0 | 21.0 | 332 | 6.9 | 111.0 |
| 7 | Miami Dolphins MIA | 16 | 46 | 10 | 13 | 3 | 0 | 21.8 | 335 | 6.9 | 110.0 |
| 8 | Los Angeles Chargers LAC | 16 | 32 | 10 | 11 | 1 | 1 | 26.5 | 361 | 5.4 | 86.0 |
| 9 | Atlanta Falcons ATL | 16 | 17 | 8 | 12 | 2 | 0 | 26.8 | 364 | 4.3 | 69.0 |
| 10 | Chicago Bears CHI | 16 | 45 | 8 | 8 | 2 | 1 | 23.5 | 315 | 5.9 | 95.0 |
| 11 | Dallas Cowboys DAL | 16 | 38 | 8 | 25 | 6 | 1 | 20.8 | 353 | 9.1 | 146.0 |
| 12 | Detroit Lions DET | 16 | 26 | 8 | 9 | 0 | 0 | 27.3 | 380 | 3.8 | 60.0 |
| 13 | Green Bay Packers GB | 16 | 38 | 8 | 18 | 2 | 0 | 20.9 | 323 | 6.4 | 102.0 |
| 14 | Houston Texans HOU | 16 | 31 | 8 | 17 | 1 | 1 | 26.5 | 383 | 5.8 | 93.0 |
| 15 | Minnesota Vikings MIN | 16 | 44 | 8 | 14 | 1 | 2 | 25.6 | 385 | 6.6 | 106.0 |
| 16 | Pittsburgh Steelers PIT | 16 | 52 | 8 | 11 | 0 | 0 | 24.1 | 360 | 5.6 | 90.0 |
| 17 | Las Vegas Raiders LV | 16 | 32 | 8 | 5 | 0 | 0 | 25.4 | 331 | 3.6 | 58.0 |
| 18 | Carolina Panthers CAR | 16 | 38 | 7 | 9 | 0 | 0 | 22.7 | 300 | 4.4 | 70.0 |
| 19 | Cincinnati Bengals CIN | 16 | 41 | 7 | 12 | 1 | 0 | 22.2 | 349 | 5.3 | 85.0 |
| 20 | New England Patriots NE | 16 | 35 | 7 | 23 | 3 | 0 | 16.9 | 312 | 7.1 | 113.0 |
| 21 | New York Giants NYG | 16 | 31 | 7 | 15 | 1 | 0 | 24.6 | 357 | 5.1 | 81.0 |
| 22 | New York Jets NYJ | 16 | 33 | 7 | 7 | 1 | 1 | 29.8 | 396 | 4.6 | 73.0 |
| 23 | Washington Commanders WAS | 16 | 35 | 7 | 9 | 2 | 1 | 26.7 | 371 | 5.3 | 85.0 |
| 24 | Cleveland Browns CLE | 16 | 39 | 6 | 13 | 2 | 0 | 22.2 | 320 | 5.6 | 89.0 |
| 25 | Denver Broncos DEN | 16 | 34 | 6 | 13 | 1 | 0 | 18.4 | 322 | 4.9 | 78.0 |
| 26 | Tennessee Titans TEN | 16 | 41 | 6 | 16 | 3 | 0 | 20.6 | 328 | 6.4 | 103.0 |
| 27 | Los Angeles Rams LAR | 16 | 47 | 6 | 17 | 0 | 1 | 21.6 | 338 | 6.2 | 99.0 |
| 28 | Baltimore Ravens BAL | 16 | 33 | 6 | 8 | 1 | 0 | 23.5 | 367 | 4.2 | 67.0 |
| 29 | Seattle Seahawks SEA | 16 | 29 | 6 | 11 | 0 | 1 | 21.0 | 384 | 4.3 | 69.0 |
| 30 | New Orleans Saints NO | 16 | 43 | 5 | 17 | 2 | 0 | 19.7 | 322 | 6.2 | 99.0 |
| 31 | Philadelphia Eagles PHI | 16 | 28 | 4 | 12 | 5 | 0 | 20.9 | 320 | 5.6 | 90.0 |
| 32 | Jacksonville Jaguars JAX | 16 | 26 | 1 | 6 | 1 | 1 | 27.9 | 361 | 3.2 | 52.0 |
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