| Rank | Name | Tm/Bye | Age | G | Cmp | Att | Cm% | PYd | Y/Att | PTD | Int | Rsh | Yd | TD | FantPt |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Tom Brady | TB/11 | 45 | 12.1 | 328.5 | 494.8 | 66.4 | 3685 | 7.45 | 27.0 | 9.4 | 19.5 | 39 | 1.2 | 247.70 |
| 2 | Patrick Mahomes II | KC/8 | 27 | 12.1 | 305.1 | 468.7 | 65.1 | 3517 | 7.50 | 24.8 | 8.9 | 46.7 | 252 | 1.7 | 257.48 |
| 3 | Justin Herbert | LAC/8 | 24 | 12.1 | 308.1 | 463.4 | 66.5 | 3479 | 7.51 | 25.7 | 10.2 | 46.8 | 224 | 2.3 | 257.76 |
| 4 | Josh Allen | BUF/7 | 26 | 12.1 | 299.4 | 461.7 | 64.8 | 3367 | 7.29 | 25.0 | 10.2 | 80.3 | 459 | 4.2 | 285.38 |
| 5 | Dak Prescott | DAL/9 | 29 | 12.0 | 297.7 | 448.9 | 66.3 | 3358 | 7.48 | 23.0 | 8.3 | 37.6 | 145 | 1.8 | 235.02 |