| Rank | Name | Tm/Bye | Age | G | Rsh | Yd | Y/R | TD | Rec | Yd | TD | FantPt |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Derrick Henry | TEN/ | 28 | 16.0 | 357.3 | 1682 | 4.7 | 14.9 | 26.4 | 232 | 0.6 | 284.40 |
| 2 | Jonathan Taylor | IND/ | 23 | 16.0 | 325.1 | 1664 | 5.1 | 14.4 | 45.9 | 392 | 1.5 | 301.00 |
| 3 | James Conner | ARI/ | 27 | 16.0 | 241.8 | 969 | 4.0 | 12.9 | 44.2 | 394 | 2.1 | 226.30 |
| 4 | Dalvin Cook | MIN/ | 27 | 16.0 | 275.8 | 1300 | 4.7 | 11.0 | 42.7 | 331 | 1.4 | 237.50 |
| 5 | Leonard Fournette | TB/ | 27 | 16.0 | 220.3 | 941 | 4.3 | 10.8 | 43.2 | 298 | 1.3 | 196.50 |