| Rank | Name | Tm/Bye | Age | G | Rsh | Yd | Y/R | TD | Rec | Yd | TD | FantPt |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Derrick Henry | TEN/13 | 27 | 15.6 | 329.5 | 1636 | 5.0 | 15.0 | 22.2 | 186 | 1.0 | 278.20 |
| 2 | Dalvin Cook | MIN/7 | 26 | 15.4 | 305.9 | 1455 | 4.8 | 14.4 | 49.9 | 413 | 1.6 | 282.80 |
| 3 | Nick Chubb | CLE/13 | 26 | 16.2 | 269.2 | 1409 | 5.2 | 13.9 | 23.2 | 199 | 1.0 | 250.20 |
| 4 | Christian McCaffrey | CAR/13 | 25 | 16.2 | 284.5 | 1266 | 4.4 | 13.0 | 85.1 | 695 | 4.0 | 298.10 |
| 5 | Alvin Kamara | NO/6 | 26 | 16.2 | 194.1 | 944 | 4.9 | 12.1 | 84.6 | 751 | 4.4 | 268.50 |