| Player | TM | Wk7 | Wk8 | Wk9 | Wk10 | Wk11 | Wk12 | Wk13 | Targ | T/TmG | T/G | REC | YD | Y/R | TD | Rec% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Deebo Samuel | SF | 11 | 9 | 9 | 5 | 2 | 4 | 0 | 92 | 7.7 | 7.7 | 56 | 1006 | 18.0 | 5 | 60.9 |
| George Kittle | SF | dnp | dnp | 8 | 7 | 4 | 2 | 12 | 61 | 5.1 | 6.8 | 44 | 606 | 13.8 | 5 | 72.1 |
| Brandon Aiyuk | SF | 1 | 7 | 8 | 4 | 7 | 6 | 6 | 54 | 4.5 | 4.5 | 35 | 487 | 13.9 | 3 | 64.8 |
| Christian McCaffrey | SF | dnp | dnp | 5 | 10 | 8 | 1 | dnp | 41 | 3.4 | 4.6 | 37 | 343 | 9.3 | 1 | 90.2 |
| Chris Conley | SF | 0 | 2 | 3 | dnp | 5 | 0 | 4 | 26 | 2.2 | 2.2 | 14 | 233 | 16.6 | 1 | 53.8 |