| Player | TM | Wk1 | Wk2 | Wk3 | Wk4 | Wk5 | Wk6 | Wk7 | Targ | T/TmG | T/G | REC | YD | Y/R | TD | Rec% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| George Kittle | SF | 5 | 0 | 0 | 15 | 8 | 10 | 7 | 45 | 6.4 | 6.4 | 35 | 435 | 12.4 | 2 | 77.8 |
| Brandon Aiyuk | SF | 0 | 3 | 8 | 5 | 6 | 3 | 7 | 32 | 4.6 | 4.6 | 20 | 280 | 14.0 | 1 | 62.5 |
| Chris Conley | SF | 1 | 7 | 8 | 4 | 2 | 2 | 2 | 26 | 3.7 | 3.7 | 15 | 224 | 14.9 | 1 | 57.7 |
| Deebo Samuel | SF | dnp | dnp | dnp | 3 | 8 | 6 | 5 | 22 | 3.1 | 5.5 | 16 | 185 | 11.6 | 1 | 72.7 |
| Kyle Juszczyk | SF | 3 | 2 | 1 | 2 | 1 | 2 | 2 | 13 | 1.9 | 1.9 | 7 | 93 | 13.3 | 0 | 53.8 |