| Player | TM | Wk12 | Wk13 | Wk14 | Wk15 | Wk16 | Wk17 | Wk18 | Targ | T/TmG | T/G | REC | YD | Y/R | TD | Rec% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| George Kittle | SF | 2 | 12 | 15 | 6 | 3 | 2 | 7 | 94 | 5.5 | 6.7 | 71 | 910 | 12.8 | 6 | 75.5 |
| Brandon Aiyuk | SF | 6 | 6 | 11 | 2 | 5 | 6 | 7 | 85 | 5.0 | 5.0 | 56 | 826 | 14.8 | 5 | 65.9 |
| Jauan Jennings | SF | 3 | 1 | 5 | 6 | 5 | 2 | 7 | 39 | 2.3 | 2.3 | 24 | 282 | 11.8 | 5 | 61.5 |
| Chris Conley | SF | 0 | 4 | 2 | 4 | 3 | 2 | 0 | 37 | 2.2 | 2.2 | 22 | 323 | 14.7 | 2 | 59.5 |
| Kyle Juszczyk | SF | 2 | 3 | 2 | 1 | 5 | 2 | 0 | 37 | 2.2 | 2.2 | 30 | 296 | 9.9 | 1 | 81.1 |