| Player | TM | Wk10 | Wk11 | Wk12 | Wk13 | Wk14 | Wk15 | Wk16 | Targ | T/TmG | T/G | REC | YD | Y/R | TD | Rec% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Deebo Samuel | SF | 5 | 2 | 4 | 0 | 1 | 5 | 11 | 109 | 7.3 | 7.3 | 70 | 1247 | 17.8 | 5 | 64.2 |
| George Kittle | SF | 7 | 4 | 2 | 12 | 15 | 6 | 3 | 85 | 5.7 | 7.1 | 65 | 871 | 13.4 | 6 | 76.5 |
| Brandon Aiyuk | SF | 4 | 7 | 6 | 6 | 11 | 2 | 5 | 72 | 4.8 | 4.8 | 46 | 625 | 13.6 | 5 | 63.9 |
| Chris Conley | SF | dnp | 5 | 0 | 4 | 2 | 4 | 3 | 35 | 2.3 | 2.3 | 21 | 325 | 15.5 | 2 | 60.0 |
| Jauan Jennings | SF | 2 | 1 | 3 | 1 | 5 | 6 | 5 | 30 | 2.0 | 2.0 | 16 | 163 | 10.2 | 3 | 53.3 |