| Player | TM | Wk6 | Wk7 | Wk8 | Wk9 | Wk10 | Wk11 | Wk12 | Targ | T/TmG | T/G | REC | YD | Y/R | TD | Rec% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Deebo Samuel | SF | - | 11 | 9 | 9 | 5 | 2 | 4 | 92 | 8.4 | 8.4 | 56 | 1006 | 18.0 | 5 | 60.9 |
| Brandon Aiyuk | SF | - | 1 | 7 | 8 | 4 | 7 | 6 | 48 | 4.4 | 4.4 | 32 | 432 | 13.5 | 3 | 66.7 |
| George Kittle | SF | - | dnp | dnp | 8 | 7 | 4 | 2 | 49 | 4.5 | 6.1 | 35 | 425 | 12.1 | 3 | 71.4 |
| Christian McCaffrey | SF | - | dnp | dnp | 5 | 10 | 8 | 1 | 41 | 3.7 | 4.6 | 37 | 343 | 9.3 | 1 | 90.2 |
| Elijah Mitchell | SF | - | 0 | 0 | 5 | 0 | 0 | 6 | 15 | 1.4 | 1.4 | 14 | 108 | 7.7 | 0 | 93.3 |