| Player | TM | Wk14 | Wk15 | Wk16 | Wk17 | Wk18 | Wk19 | Wk20 | Targ | T/TmG | T/G | REC | YD | Y/R | TD | Rec% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Deebo Samuel | SF | 1 | 5 | 11 | 6 | 6 | 3 | 4 | 128 | 6.7 | 6.7 | 83 | 1487 | 17.9 | 6 | 64.8 |
| George Kittle | SF | 15 | 6 | 3 | 2 | 7 | 3 | 6 | 103 | 5.4 | 6.4 | 76 | 991 | 13.0 | 6 | 73.8 |
| Brandon Aiyuk | SF | 11 | 2 | 5 | 6 | 7 | 6 | 1 | 92 | 4.8 | 4.8 | 61 | 892 | 14.6 | 5 | 66.3 |
| Jauan Jennings | SF | 5 | 6 | 5 | 2 | 7 | 5 | 2 | 46 | 2.4 | 2.4 | 28 | 317 | 11.3 | 5 | 60.9 |
| Christian McCaffrey | SF | dnp | 0 | dnp | dnp | dnp | dnp | dnp | 41 | 2.2 | 4.1 | 37 | 343 | 9.3 | 1 | 90.2 |