| Player | TM | Wk11 | Wk12 | Wk13 | Wk14 | Wk15 | Wk16 | Wk17 | Targ | T/TmG | T/G | REC | YD | Y/R | TD | Rec% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Christian McCaffrey | SF | 14 | 9 | 13 | 12 | 10 | 15 | 10 | 143 | 8.9 | 8.9 | 116 | 1005 | 8.7 | 4 | 81.1 |
| George Kittle | SF | 0 | 6 | 4 | 8 | 17 | 8 | 7 | 107 | 6.7 | 7.1 | 85 | 1053 | 12.4 | 5 | 79.4 |
| Deebo Samuel | SF | 10 | 2 | 4 | 8 | 3 | 6 | 5 | 81 | 5.1 | 5.4 | 57 | 803 | 14.1 | 3 | 70.4 |
| Chris Conley | SF | 8 | 9 | 5 | 3 | 8 | 5 | 6 | 91 | 5.7 | 5.7 | 47 | 775 | 16.5 | 5 | 51.6 |
| Kyle Juszczyk | SF | 7 | 0 | 0 | 3 | 2 | 2 | 1 | 24 | 1.5 | 2.0 | 20 | 239 | 11.9 | 1 | 83.3 |