| Player | TM | Wk14 | Wk15 | Wk16 | Wk17 | Wk18 | Wk19 | Wk20 | Targ | T/TmG | T/G | REC | YD | Y/R | TD | Rec% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Christian McCaffrey | SF | 12 | 10 | 15 | 10 | - | dnp | dnp | 143 | 7.9 | 8.9 | 116 | 1005 | 8.7 | 4 | 81.1 |
| George Kittle | SF | 8 | 17 | 8 | 7 | - | 5 | 1 | 113 | 6.3 | 6.6 | 89 | 1088 | 12.2 | 5 | 78.8 |
| Deebo Samuel | SF | 8 | 3 | 6 | 5 | - | 6 | 3 | 90 | 5.0 | 5.3 | 62 | 891 | 14.4 | 3 | 68.9 |
| Chris Conley | SF | 3 | 8 | 5 | 6 | - | dnp | dnp | 91 | 5.1 | 5.7 | 47 | 775 | 16.5 | 5 | 51.6 |
| Kyle Juszczyk | SF | 3 | 2 | 2 | 1 | - | 0 | 0 | 24 | 1.3 | 1.7 | 20 | 239 | 11.9 | 1 | 83.3 |