| Player | TM | Wk8 | Wk9 | Wk10 | Wk11 | Wk12 | Wk13 | Wk14 | Targ | T/TmG | T/G | REC | YD | Y/R | TD | Rec% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Deebo Samuel | SF | 9 | 9 | 5 | 2 | 4 | 0 | 1 | 93 | 7.2 | 7.2 | 57 | 1028 | 18.0 | 5 | 61.3 |
| George Kittle | SF | dnp | 8 | 7 | 4 | 2 | 12 | 15 | 76 | 5.8 | 7.6 | 57 | 757 | 13.3 | 6 | 75.0 |
| Brandon Aiyuk | SF | 7 | 8 | 4 | 7 | 6 | 6 | 11 | 65 | 5.0 | 5.0 | 41 | 549 | 13.4 | 4 | 63.1 |
| Christian McCaffrey | SF | dnp | 5 | 10 | 8 | 1 | dnp | dnp | 41 | 3.2 | 4.6 | 37 | 343 | 9.3 | 1 | 90.2 |
| Chris Conley | SF | 2 | 3 | dnp | 5 | 0 | 4 | 2 | 28 | 2.2 | 2.2 | 16 | 253 | 15.8 | 1 | 57.1 |