NOTE: only players with at least 2 targets per week are shown.
| Player | TM | Wk10 | Wk11 | Wk12 | Wk13 | Wk14 | Wk15 | Wk16 | Targ | T/TmG | T/G | REC | YD | Y/R | TD | Rec% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Christian McCaffrey | SF | 10 | 8 | 1 | dnp | dnp | 0 | dnp | 41 | 2.7 | 4.1 | 37 | 343 | 9.3 | 1 | 90.2 |
| Kyle Juszczyk | SF | 1 | 2 | 2 | 3 | 2 | 1 | 5 | 35 | 2.3 | 2.3 | 28 | 287 | 10.2 | 1 | 80.0 |
| George Kittle | SF | 7 | 4 | 2 | 12 | 15 | 6 | 3 | 85 | 5.7 | 7.1 | 65 | 871 | 13.4 | 6 | 76.5 |
| Deebo Samuel | SF | 5 | 2 | 4 | 0 | 1 | 5 | 11 | 109 | 7.3 | 7.3 | 70 | 1247 | 17.8 | 5 | 64.2 |
| Brandon Aiyuk | SF | 4 | 7 | 6 | 6 | 11 | 2 | 5 | 72 | 4.8 | 4.8 | 46 | 625 | 13.6 | 5 | 63.9 |
