| Player | TM | Wk12 | Wk13 | Wk14 | Wk15 | Wk16 | Wk17 | Wk18 | Targ | T/TmG | T/G | REC | YD | Y/R | TD | Rec% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Deebo Samuel | SF | 4 | 0 | 1 | 5 | 11 | 6 | 6 | 121 | 7.1 | 7.1 | 77 | 1405 | 18.2 | 6 | 63.6 |
| George Kittle | SF | 2 | 12 | 15 | 6 | 3 | 2 | 7 | 94 | 5.5 | 6.7 | 71 | 910 | 12.8 | 6 | 75.5 |
| Brandon Aiyuk | SF | 6 | 6 | 11 | 2 | 5 | 6 | 7 | 85 | 5.0 | 5.0 | 56 | 826 | 14.8 | 5 | 65.9 |
| Christian McCaffrey | SF | 1 | dnp | dnp | 0 | dnp | dnp | dnp | 41 | 2.4 | 4.1 | 37 | 343 | 9.3 | 1 | 90.2 |
| Chris Conley | SF | 0 | 4 | 2 | 4 | 3 | 2 | 0 | 37 | 2.2 | 2.2 | 22 | 323 | 14.7 | 2 | 59.5 |