| Player | TM | Wk3 | Wk4 | Wk5 | Wk6 | Wk7 | Wk8 | Wk9 | Targ | T/TmG | T/G | REC | YD | Y/R | TD | Rec% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Deebo Samuel | SF | 10 | 13 | 9 | - | 11 | 9 | 9 | 81 | 10.1 | 10.1 | 49 | 882 | 18.0 | 4 | 60.5 |
| George Kittle | SF | 9 | 10 | dnp | - | dnp | dnp | 8 | 36 | 4.5 | 7.2 | 25 | 328 | 13.1 | 1 | 69.4 |
| Brandon Aiyuk | SF | 6 | 3 | 4 | - | 1 | 7 | 8 | 31 | 3.9 | 3.9 | 19 | 230 | 12.1 | 2 | 61.3 |
| Christian McCaffrey | SF | 2 | 0 | 0 | - | dnp | dnp | 5 | 22 | 2.8 | 3.7 | 20 | 217 | 10.8 | 0 | 90.9 |
| Kyle Juszczyk | SF | 4 | 4 | 4 | - | 0 | 1 | 2 | 19 | 2.4 | 2.4 | 17 | 160 | 9.4 | 1 | 89.5 |