| Rank | Name | Tm/Bye | Age | G | Cmp | Att | Cm% | PYd | Y/Att | PTD | Int | Rsh | Yd | TD | FantPt |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Tom Brady | TB/11 | 45 | 16.7 | 454.2 | 681.6 | 66.6 | 5082 | 7.46 | 38.5 | 12.7 | 27.0 | 53 | 1.8 | 411.50 |
| 2 | Joe Burrow | CIN/10 | 26 | 16.7 | 392.8 | 558.0 | 70.4 | 4877 | 8.74 | 36.5 | 12.7 | 45.8 | 154 | 2.5 | 407.55 |
| 3 | Patrick Mahomes II | KC/8 | 27 | 16.7 | 419.6 | 643.2 | 65.2 | 4819 | 7.49 | 34.6 | 11.8 | 63.7 | 350 | 2.6 | 418.15 |
| 4 | Justin Herbert | LAC/8 | 24 | 16.7 | 424.0 | 635.9 | 66.7 | 4784 | 7.52 | 36.3 | 13.7 | 64.7 | 309 | 3.3 | 421.40 |
| 5 | Derek Carr | LV/6 | 31 | 16.7 | 420.5 | 608.8 | 69.1 | 4733 | 7.77 | 29.0 | 12.3 | 38.4 | 115 | 1.0 | 357.85 |