| Rank | Name | Tm/Bye | Age | G | Cmp | Att | Cm% | PYd | Y/Att | PTD | Int | Rsh | Yd | TD | FantPt |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Tom Brady | TB/11 | 45 | 12.1 | 328.5 | 494.8 | 66.4 | 3685 | 7.45 | 27.0 | 9.4 | 19.5 | 39 | 1.2 | 247.70 |
| 2 | Patrick Mahomes II | KC/8 | 27 | 12.1 | 305.1 | 468.7 | 65.1 | 3517 | 7.50 | 24.8 | 8.9 | 46.7 | 252 | 1.7 | 257.48 |
| 3 | Joe Burrow | CIN/10 | 26 | 12.1 | 283.9 | 408.1 | 69.6 | 3512 | 8.61 | 25.9 | 9.5 | 33.1 | 109 | 1.7 | 246.18 |
| 4 | Justin Herbert | LAC/8 | 24 | 12.1 | 308.1 | 463.4 | 66.5 | 3479 | 7.51 | 25.7 | 10.2 | 46.8 | 224 | 2.3 | 257.76 |
| 5 | Derek Carr | LV/6 | 31 | 12.1 | 304.7 | 443.5 | 68.7 | 3421 | 7.71 | 21.4 | 9.3 | 28.1 | 83 | 0.7 | 216.34 |