| Rank | Name | Tm/Bye | Age | G | Rsh | Yd | Y/R | TD | Rec | Yd | TD | FantPt |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Nick Chubb | CLE/ | 27 | 16.0 | 249.1 | 1327 | 5.3 | 9.6 | 22.6 | 187 | 0.9 | 214.40 |
| 2 | Rashaad Penny | SEA/ | 26 | 15.5 | 155.0 | 815 | 5.3 | 5.9 | 15.1 | 131 | 0.3 | 131.80 |
| 3 | Kene Nwangwu | MIN/ | 16.0 | 6.1 | 32 | 5.2 | 0.5 | 3.8 | 18 | 0.0 | 8.00 | |
| 4 | Tony Pollard | DAL/ | 25 | 16.0 | 146.5 | 758 | 5.2 | 4.0 | 46.3 | 355 | 1.2 | 142.50 |
| 5 | Tyrion Davis-Price | SF/ | 16.0 | 58.1 | 296 | 5.1 | 1.2 | 5.3 | 42 | 0.1 | 41.60 |