| Player | TM | Wk11 | Wk12 | Wk13 | Wk14 | Wk15 | Wk16 | Wk17 | Targ | T/TmG | T/G | REC | YD | Y/R | TD | Rec% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| George Kittle | SF | 4 | 2 | 12 | 15 | 6 | 3 | 2 | 87 | 5.4 | 6.7 | 66 | 900 | 13.6 | 6 | 75.9 |
| Brandon Aiyuk | SF | 7 | 6 | 6 | 11 | 2 | 5 | 6 | 78 | 4.9 | 4.9 | 50 | 719 | 14.4 | 5 | 64.1 |
| Trent Sherfield Sr. | SF | 0 | 1 | 5 | 0 | 1 | 0 | 2 | 19 | 1.2 | 1.2 | 8 | 74 | 9.2 | 1 | 42.1 |
| Kyle Juszczyk | SF | 2 | 2 | 3 | 2 | 1 | 5 | 2 | 37 | 2.3 | 2.3 | 30 | 296 | 9.9 | 1 | 81.1 |
| Elijah Mitchell | SF | 0 | 6 | 3 | 0 | 0 | 0 | 2 | 20 | 1.2 | 1.2 | 19 | 137 | 7.2 | 1 | 95.0 |