NOTE: only players with at least 2 targets per week are shown.
| Player | TM | Wk9 | Wk10 | Wk11 | Wk12 | Wk13 | Wk14 | Wk15 | Targ | T/TmG | T/G | REC | YD | Y/R | TD | Rec% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Christian McCaffrey | SF | 5 | 10 | 8 | 1 | dnp | dnp | 0 | 41 | 2.9 | 4.1 | 37 | 343 | 9.3 | 1 | 90.2 |
| Kyle Juszczyk | SF | 2 | 1 | 2 | 2 | 3 | 2 | 1 | 30 | 2.1 | 2.1 | 25 | 242 | 9.7 | 1 | 83.3 |
| George Kittle | SF | 8 | 7 | 4 | 2 | 12 | 15 | 6 | 82 | 5.9 | 7.5 | 63 | 850 | 13.5 | 6 | 76.8 |
| Brandon Aiyuk | SF | 8 | 4 | 7 | 6 | 6 | 11 | 2 | 67 | 4.8 | 4.8 | 42 | 585 | 13.9 | 4 | 62.7 |
| Deebo Samuel Sr. | SF | 9 | 5 | 2 | 4 | 0 | 1 | 5 | 98 | 7.0 | 7.0 | 61 | 1088 | 17.8 | 5 | 62.2 |
