| Player | TM | Wk4 | Wk5 | Wk6 | Wk7 | Wk8 | Wk9 | Wk10 | Targ | T/TmG | T/G | REC | YD | Y/R | TD | Rec% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Marqise Lee | SF | 3 | 4 | 10 | 6 | dnp | 12 | 11 | 69 | 6.9 | 7.7 | 38 | 493 | 13.0 | 2 | 55.1 |
| Christian McCaffrey | SF | 6 | 7 | 14 | 9 | 7 | 6 | 7 | 79 | 7.9 | 7.9 | 57 | 433 | 7.6 | 3 | 72.2 |
| George Kittle | SF | 3 | 9 | 8 | 2 | 4 | 5 | dnp | 42 | 4.2 | 4.7 | 27 | 277 | 10.3 | 1 | 64.3 |
| Trent Taylor | SF | 10 | 2 | 5 | 5 | 3 | 3 | dnp | 37 | 3.7 | 4.1 | 24 | 204 | 8.5 | 1 | 64.9 |
| Bennie Fowler | SF | 2 | dnp | 8 | 5 | 6 | 2 | 1 | 38 | 3.8 | 4.2 | 20 | 220 | 11.0 | 2 | 52.6 |