| Name | Team | Opp | RSH | YD | TD | REC | YD | TD | FPT | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Derrick Henry | TEN | vs CIN | 23 | 100 | 0.88 | 1.80 | 18 | 0.05 | 17.4 | |
| 2 | Austin Ekeler | LAC | at ARI | 14 | 60 | 0.68 | 6.50 | 44 | 0.38 | 16.7 | |
| 3 | Josh Jacobs | LV | at SEA | 19 | 89 | 0.63 | 3.20 | 24 | 0.10 | 15.7 | |
| 4 | Ken Walker III | SEA | vs LV | 19 | 87 | 0.80 | 2.20 | 14 | 0.10 | 15.5 | |
| 5 | Saquon Barkley | NYG | at DAL | 20 | 88 | 0.59 | 3.00 | 19 | 0.10 | 14.8 |