| Name | Team | Opp | RSH | YD | TD | REC | YD | TD | FPT | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Derrick Henry | TEN | at WAS | 22 | 92 | 0.69 | 2.20 | 21 | 0.10 | 16.0 | |
| 2 | Nick Chubb | CLE | vs LAC | 18 | 93 | 0.79 | 1.40 | 10 | 0.06 | 15.4 | |
| 3 | Saquon Barkley | NYG | at GB | 19 | 80 | 0.40 | 4.20 | 27 | 0.12 | 13.8 | |
| 4 | Austin Ekeler | LAC | at CLE | 12 | 50 | 0.46 | 5.40 | 40 | 0.34 | 13.8 | |
| 5 | Joe Mixon | CIN | at BAL | 19 | 74 | 0.50 | 3.40 | 24 | 0.16 | 13.8 |