| Name | Team | Opp | RSH | YD | TD | REC | YD | TD | FPT | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Christian McCaffrey | SF | at LV | 17 | 74 | 0.65 | 4.40 | 34 | 0.30 | 20.9 | |
| 2 | Austin Ekeler | LAC | vs LAR | 13 | 54 | 0.65 | 5.60 | 37 | 0.27 | 20.3 | |
| 3 | Saquon Barkley | NYG | vs IND | 19 | 78 | 0.72 | 3.70 | 22 | 0.10 | 18.6 | |
| 4 | James Conner | ARI | at ATL | 18 | 74 | 0.55 | 3.90 | 26 | 0.10 | 17.8 | |
| 5 | Travis Etienne | JAX | at HOU | 20 | 89 | 0.50 | 2.10 | 19 | 0.10 | 16.5 |