| Rank | Name | Tm/Bye | Age | G | Rsh | Yd | Y/R | TD | Rec | Yd | TD | FantPt |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Derrick Henry | TEN/6 | 28 | 15.5 | 344.2 | 1543 | 4.5 | 13.1 | 27.9 | 238 | 1.0 | 262.70 |
| 2 | Jonathan Taylor | IND/14 | 23 | 15.9 | 319.6 | 1651 | 5.2 | 16.5 | 42.7 | 371 | 1.8 | 312.00 |
| 3 | Najee Harris | PIT/9 | 24 | 15.9 | 290.0 | 1156 | 4.0 | 8.0 | 67.1 | 456 | 2.8 | 226.00 |
| 4 | Joe Mixon | CIN/10 | 26 | 15.9 | 288.0 | 1217 | 4.2 | 12.1 | 45.5 | 340 | 3.0 | 246.30 |
| 5 | Dalvin Cook | MIN/7 | 27 | 15.2 | 268.4 | 1247 | 4.6 | 10.2 | 46.1 | 359 | 1.9 | 233.20 |