| Rank | Name | Tm/Bye | Age | G | Rsh | Yd | Y/R | TD | Rec | Yd | TD | FantPt |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jonathan Taylor | IND/14 | 23 | 11.6 | 228.6 | 1157 | 5.1 | 11.1 | 30.8 | 262 | 1.2 | 215.70 |
| 2 | Derrick Henry | TEN/6 | 28 | 11.4 | 245.9 | 1114 | 4.5 | 8.7 | 20.6 | 172 | 0.7 | 185.00 |
| 3 | Christian McCaffrey | SF/9 | 26 | 10.9 | 167.7 | 742 | 4.4 | 6.5 | 60.8 | 520 | 2.8 | 182.00 |
| 4 | Joe Mixon | CIN/10 | 26 | 11.6 | 210.4 | 887 | 4.2 | 8.5 | 30.6 | 228 | 1.9 | 173.90 |
| 5 | Austin Ekeler | LAC/8 | 27 | 11.4 | 147.8 | 663 | 4.5 | 6.3 | 51.2 | 469 | 3.8 | 173.80 |