| Rank | Name | Tm/Bye | Age | G | Rsh | Yd | Y/R | TD | Rec | Yd | TD | FantPt |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jonathan Taylor | IND/ | 23 | 16.0 | 315.3 | 1612 | 5.1 | 13.8 | 43.5 | 372 | 1.4 | 289.60 |
| 2 | Derrick Henry | TEN/ | 28 | 16.0 | 357.3 | 1682 | 4.7 | 14.9 | 26.4 | 232 | 0.6 | 284.40 |
| 3 | Christian McCaffrey | CAR/ | 26 | 15.5 | 239.7 | 1091 | 4.6 | 9.4 | 82.4 | 692 | 3.2 | 253.90 |
| 4 | Austin Ekeler | LAC/ | 27 | 16.0 | 211.4 | 976 | 4.6 | 7.6 | 70.7 | 667 | 5.7 | 244.10 |
| 5 | Alvin Kamara | NO/ | 27 | 16.0 | 219.3 | 969 | 4.4 | 9.3 | 69.1 | 600 | 4.3 | 238.50 |