| Rank | Name | Tm/Bye | Age | G | Rsh | Yd | Y/R | TD | Rec | Yd | TD | FantPt |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Christian McCaffrey | CAR/13 | 25 | 16.1 | 294.2 | 1339 | 4.6 | 13.5 | 85.2 | 704 | 4.1 | 309.90 |
| 2 | Derrick Henry  | TEN/13 | 27 | 15.7 | 344.4 | 1713 | 5.0 | 15.8 | 23.4 | 197 | 1.1 | 292.40 |
| 3 | Dalvin Cook | MIN/7 | 26 | 15.5 | 312.7 | 1492 | 4.8 | 14.4 | 52.6 | 439 | 1.6 | 289.10 |
| 4 | Alvin Kamara | NO/6 | 26 | 16.1 | 198.0 | 970 | 4.9 | 12.1 | 88.5 | 786 | 4.7 | 276.40 |
| 5 | Jonathan Taylor | IND/14 | 22 | 16.1 | 278.5 | 1343 | 4.8 | 12.2 | 37.7 | 308 | 1.5 | 247.30 |