| Player | TM | Wk11 | Wk12 | Wk13 | Wk14 | Wk15 | Wk16 | Wk17 | Targ | T/TmG | T/G | REC | YD | Y/R | TD | Rec% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Christian McCaffrey | SF | 5 | 6 | 4 | 1 | 5 | 10 | 5 | 83 | 5.2 | 5.2 | 67 | 564 | 8.4 | 7 | 80.7 |
| Jerome Ford | CLE | 5 | 7 | 3 | 6 | 5 | 2 | 3 | 60 | 3.8 | 3.8 | 42 | 293 | 7.0 | 5 | 70.0 |
| Saquon Barkley | PHI | 5 | 3 | dnp | 4 | 2 | 6 | 6 | 58 | 3.6 | 4.5 | 39 | 229 | 5.9 | 4 | 67.2 |
| James Cook | BUF | 4 | 7 | - | 5 | 3 | 0 | 3 | 50 | 3.1 | 3.1 | 41 | 429 | 10.5 | 4 | 82.0 |
| Breece Hall | NYJ | 6 | 9 | 8 | 9 | 2 | 16 | 9 | 93 | 5.8 | 5.8 | 74 | 579 | 7.8 | 4 | 79.6 |