| Name | Team | Opp | CMP | ATT | PYD | PTD | INT | RSH | YD | TD | FPT | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Josh Allen | BUF | at LAR | 27 | 40 | 300 | 1.70 | 0.80 | 7 | 40 | 0.30 | 26.8 | |
| 2 | Kyler Murray | ARI | vs KC | 25 | 36 | 273 | 1.80 | 0.80 | 6 | 31 | 0.30 | 24.9 | |
| 3 | Dak Prescott | DAL | vs TB | 26 | 39 | 290 | 1.90 | 0.60 | 3 | 14 | 0.30 | 24.7 | |
| 4 | Patrick Mahomes II | KC | at ARI | 24 | 37 | 270 | 1.80 | 0.70 | 4 | 24 | 0.20 | 23.6 | |
| 5 | Jalen Hurts | PHI | at DET | 18 | 28 | 218 | 1.30 | 0.60 | 10 | 56 | 0.40 | 23.5 |