| Name | Team | Opp | RSH | YD | TD | REC | YD | TD | FPT | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jonathan Taylor | IND | at JAX | 21 | 105 | 0.91 | 3.00 | 23 | 0.10 | 18.9 | |
| 2 | Christian McCaffrey | SF | vs SEA | 16 | 69 | 0.57 | 5.60 | 46 | 0.29 | 16.7 | |
| 3 | Joe Mixon | CIN | at DAL | 20 | 83 | 0.66 | 3.10 | 23 | 0.16 | 15.6 | |
| 4 | Dalvin Cook | MIN | at PHI | 18 | 85 | 0.56 | 3.50 | 25 | 0.10 | 15.0 | |
| 5 | Derrick Henry | TEN | at BUF | 21 | 89 | 0.64 | 2.10 | 16 | 0.06 | 14.7 |