| Name | Team | Opp | RSH | YD | TD | REC | YD | TD | FPT | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jonathan Taylor | IND | vs TEN | 21 | 101 | 0.74 | 2.50 | 19 | 0.12 | 17.2 | |
| 2 | Saquon Barkley | NYG | vs CHI | 19 | 83 | 0.59 | 4.20 | 30 | 0.16 | 15.8 | |
| 3 | Nick Chubb | CLE | at ATL | 18 | 92 | 0.80 | 1.30 | 10 | 0.06 | 15.4 | |
| 4 | Christian McCaffrey | SF | vs LAR | 16 | 73 | 0.45 | 3.70 | 27 | 0.22 | 14.0 | |
| 5 | Austin Ekeler | LAC | at HOU | 13 | 56 | 0.46 | 5.40 | 38 | 0.28 | 13.8 |