| Player | TM | Wk9 | Wk10 | Wk11 | Wk12 | Wk13 | Wk14 | Wk15 | Targ | T/TmG | T/G | REC | YD | Y/R | TD | Rec% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| George Kittle | SF | - | 4 | dnp | 6 | 2 | 6 | 7 | 74 | 5.3 | 6.2 | 60 | 861 | 14.3 | 8 | 81.1 |
| Jauan Jennings | SF | - | 11 | 11 | 7 | 5 | 8 | 9 | 87 | 6.2 | 7.2 | 59 | 805 | 13.6 | 6 | 67.8 |
| Ricky Pearsall | SF | - | 6 | 2 | 0 | 1 | 2 | 4 | 24 | 1.7 | 3.0 | 13 | 153 | 11.8 | 1 | 54.2 |
| Deebo Samuel Sr. | SF | - | 6 | 7 | 4 | 5 | 3 | 7 | 71 | 5.1 | 5.5 | 43 | 569 | 13.2 | 1 | 60.6 |
| Brandon Aiyuk | SF | - | dnp | dnp | dnp | dnp | dnp | dnp | 47 | 3.4 | 6.7 | 25 | 374 | 15.0 | 0 | 53.2 |