FanDuel Top 10 Plays Week 10

Breaking Down 10 of the Most Popular Plays on FanDuel

Devin Knotts's FanDuel Top 10 Plays Week 10 Devin Knotts Published 11/14/2026

FanDuel Top 10 Week 10

Top 10 FanDuel DFS Plays for NFL Week 10

Week 10 runs without four teams, with the Chicago Bears, Denver Broncos, Philadelphia Eagles and Tampa Bay Buccaneers on bye. San Francisco at Dallas has a 55.5 total, the highest on the slate, with San Francisco implied for 29.5 as a 3.5-point road favorite. Buffalo is also implied for 29.5 as an 8.5-point road favorite at the Jets. Jacksonville is implied for 28.5 as a 10.5-point road favorite at Tennessee, the biggest spread on the board, and Carolina at New Orleans carries a 48.5 total. Injuries are shrinking the target trees again. Dallas will be without Jake Ferguson and Tyler Goodson for multiple weeks, and Mike Evans isn’t expected to be ready for San Francisco. Below are 10 plays broken down by position, including two quarterbacks from the same game. 

Quarterback

Brock Purdy, San Francisco 49ers, $8,700 (at Dallas)

Purdy is the most efficient quarterback in football right now. He leads the NFL at 0.321 EPA per play. He also gave fantasy managers a rushing floor last week, completing 17 of 25 passes for 232 yards, two touchdowns and an interception against the Raiders while running seven times for 40 yards and a score. Dallas is a pass defense you want to attack. The Cowboys rank 24th in passing points allowed per game (15.7), 26th in completion rate allowed (65.6 percent) and 24th in touchdown rate allowed (5.4 percent). Two weeks ago, Gardner Minshew threw for 188 yards and three touchdowns against them in just over a quarter plus overtime. Their secondary is getting thinner, too. Dallas has ruled out safety P.J. Locke, which leaves Malik Hooker and Caleb Downs as its only starting-caliber safeties, and a decision on Joey Porter Jr. is expected at the end of the week. This game has the highest total on the slate at 55.5, and San Francisco is implied for 29.75 points. With Keenan Allen arriving by trade and Deebo Samuel practicing, Purdy is the safest way into the best game environment on the board.

Dak Prescott, Dallas Cowboys, $7,900 (vs. San Francisco)

Already a subscriber?

Continue reading this content with a ELITE subscription.

An ELITE subscription is required to access content for DFS leagues. If this league is not a DFS league, you can edit your leagues here.

Photos provided by Imagn Images
Share This Article

More by Devin Knotts

 

DraftKings Top 10 Plays

Devin Knotts

Breaking Down 10 of the Most Popular Plays on DraftKings

11/14/26 Read More
 

Cracking FanDuel Week 10

Devin Knotts

Devin Knotts breaks down his Week 10 thoughts while giving you the top cash game plays.

11/14/26 Read More
 

Cracking DraftKings Week 10

Devin Knotts

Devin Knotts breaks down his Week 10 thoughts while giving you the top cash game plays.

11/14/26 Read More
 

Passing Matchups Week 10

Devin Knotts

A top-to-bottom ranking of this week's NFL passing matchups, while providing details on both sides of the ball for the best and the worst pairings.

11/12/26 Read More
 

Rushing Matchups Week 10

Devin Knotts

A top-to-bottom ranking of this week's NFL rushing matchups, while providing details on both sides of the ball for the best and the worst pairings.

11/12/26 Read More
 

Cracking DraftKings

Devin Knotts

Devin Knotts breaks down his Week 9 thoughts while giving you the top cash game plays.

11/07/26 Read More