Welcome back to NFL Prop Talk, highlighting the best Week 16 NFL player props!
Another 2-0 week has finally led us to a winning record on the 2025 NFL season, with little time to spare. We are currently 25-23 on tracked plays for this season, and it's time to end the season on a strong note.
Prop Talk is Footballguys' leading NFL player props weekly article. We will utilize a combination of Footballguys' fantastic tools, rankings, and projections, along with my insights, to help you determine whether a player will go over or under their weekly player prop number and potentially win some money.
Let's dive right into some Week 16 NFL player props.
Week 16 NFL Player Props
We'll be using many different sportsbooks for these Week 16 NFL player props lines. Our advice is to always line-shop at as many sportsbooks as possible to find the best possible line!
Jakobi Meyers Over/Under 54.5 Receiving Yards (DraftKings)
Since arriving in Jacksonville six weeks ago, Meyers has helped transform the Jaguars' passing attack from a middling unit that had just lost rookie Travis Hunter to a season-ending injury to an above-average group that has seen QB Trevor Lawrence have some special performances.
Meyers hasn't lit up the stat sheet, with a 3-3 record on this Week 16 NFL player prop as a Jaguar, but he is the top option in this passing attack and just signed a new three-year contract to prove it. With that situation handled, Meyers is free to go to work against the Denver Broncos this weekend.
The Broncos run the third-heaviest amount of man coverage in the NFL this season, but Meyers should draw a matchup against CB2 Riley Moss rather than superstar CB Patrick Surtain II, who is projected to shadow WR Brian Thomas Jr. instead, per ESPN's Shadow Report. The Broncos allow the ninth-most receiving yards to WR2s, and Meyers should be able to zoom over his receiving yards total in this one.
PICK: Meyers OVER 54.5 receiving yards (-110)
