DraftKings Top 10 Plays

Breaking Down 10 of the Most Popular Plays on DraftKings

Devin Knotts's DraftKings Top 10 Plays Devin Knotts Published 10/17/2026

Top 10 DraftKings DFS Plays for NFL Week 6

The Texans and Jaguars play overseas Sunday morning, which leaves a 10 game main slate on DraftKings. Three games stand out on the board. Bills at Raiders carries a 53.5 total, while Bears at Falcons and Cardinals at Rams both sit at 51.5. The Rams own the highest implied team total of the week at 32 points as 12.5 point favorites, and Arizona has allowed the most points per game in the league.

Injuries are shaping the rest of the slate. Lamar Jackson, Jalen Hurts, Saquon Barkley, Baker Mayfield, Jeremiyah Love and Rashee Rice are all out. Below are 10 plays worth building around, broken down by position with the reasoning behind each one.

Quarterback

Josh Allen, Buffalo Bills, $7,500 (at Las Vegas)

Allen is in the best game environment on the slate, with a 53.5 point total and a Buffalo implied total of 29. His rushing is what sets him apart. He ran 10 times for 121 yards last week and already has eight rushing touchdowns on the season, which gives him a floor no other quarterback on the board can match. Buffalo ranks 28th against quarterbacks, so the Raiders should be able to push back and keep Allen throwing into the fourth quarter. The best pairing is simple: Allen with Brock Bowers from the other side of the game. You can easily add in Keon Coleman, or go with a two tight-end build with Dalton Kincaid. 

Matthew Stafford, L.A. Rams, $6,400 (vs. Arizona)

Stafford leads the NFL in completions, attempts and passing yards, and he has thrown at least 50 passes in three straight games. The 12.5 point spread raises a fair concern about him sitting late in a blowout, and the Rams probably won't need 50 attempts this week. Even at 30 attempts, the matchup carries him. Arizona has allowed the most passing touchdowns in the league (14), the highest yards per reception (14.3) and ranks 31st in opponent passer rating. At $6,400 he's well below Allen, which leaves room for two of the expensive running backs on this list.

Running Back

Bijan Robinson, Atlanta Falcons, $8,700 (vs. Chicago)

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