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These contests are intended to be fun as you’re watching the game. It’s incredibly difficult to get a real edge as there are so few options, and in MME contests, there are often many duplicate lineups. One play or one penalty can change the entire outcome of the game.
The 49ers are 8.5-point favorites against the Cardinals in Mexico, and Kyler Murray is a game-time decision due to a hamstring injury. The majority of lineups should consist of 49ers in this one.
- Zach Ertz OUT
- Marquise Brown OUT
- Kyler Murray Questionable/Game Time Decision
- DeAndre Hopkins Questionable
San Francisco 49ers
Jimmy Garoppolo - Captain/Flex
Jimmy Garoppolo leads a 49ers offense that ranks seventh in EPA/Play and fourth in Success Rate. He has a decent matchup against a Cardinals defense that ranks 13th in EPA/Play Allowed, 13th in Dropback EPA Allowed, and 30th in Success Rate. And prior to last week, Garoppolo had two touchdown passes in four straight games.
Running Back/Wide Receiver/Tight End
Christian McCaffrey - Captain/Flex
Christian McCaffrey ranks seventh in the league in opportunities per game (20.6) and eighth in total yards per game (106.4) and has a favorable matchup against a Cardinals defense that ranks 13th in EPA/Play Allowed, 17th in Rush EPA Allowed, and 30th in Success Rate. With the 49ers being 8.5-point favorites in this one, McCaffrey is the best captain play.
George Kittle - Captain/Flex
Prior to last week, George Kittle had scored a touchdown in back-to-back games and now gets to play against a Cardinals defense that has allowed the second-most fantasy points per game to the tight end position this season. Kittle is in a smash spot.
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