Buy Low
Dak Prescott (QB-DAL) - Prescott actually played about as well as any quarterback in Week 1, but his receivers let him down repeatedly with drops, and both touchdowns came on the ground. He's going to be fine, in part because the Cowboys' line looks really good, and we know CeeDee Lamb has better hands than what we saw in Week 1.
Jaydon Blue (RB-DAL) - The Cowboys said they want more consistency from Blue before they make him active, and it's possible that he stays in the doghouse all year. If he can get out of it, he'll be running behind a line that had one of the best yards before contact numbers of any in Week 1. Unlike Miles Sanders, Blue isn't getting caught from behind when he gets in the open. Unlike Javonte Williams, Blue actually has the burst to get into the open.
Calvin Ridley, Elic Ayomanor (WR-TEN) - Cam Ward certainly learned some lessons in his debut, but his failure wasn't for lack of trying. Some drops let him down, and maybe he hung in too long instead of throwing the ball away under pressure. But there aren't going to be many quarterbacks who slice and dice the Broncos' defense this year. As Ward and this offense improve, the big plays downfield are going to come. Ridley won't face Patrick Surtain II every week, and Ayomanor was the clear #2 receiver in his debut.
Brian Robinson Jr (RB-SF) - Yes, Christian McCaffrey held up under 31 touches in Week 1, and he doesn't appear any worse for the wear, but don't you get a sense of dread watching him now? With Brock Purdy out for at least a few weeks, George Kittle out for at least four, and Jauan Jennings nursing a new injury, there's an even bigger chance the 49ers overwork McCaffrey. Robinson is one of the highest-priority backup running backs to stash.
Joshua Palmer (WR-BUF) - Palmer didn't have a massive Week 1, but he was a decent PPR play, and he got the same number of targets as Khalil Shakir. Keon Coleman had the big game in Week 1, but with Josh Allen slinging it and the Bills' defense playing matador defense, the passing volume should be up in Buffalo this year. Palmer is going to have days when he feasts in the "everybody eats" offense.
Nick Chubb (RB-HOU) - The Texans are going to give Chubb a chance to be their season's savior. The line, his age, and injuries might not allow for it, but Demeco Ryans noted that Chubb got stronger as the game went on and said that they will give him a bigger role in Week 2. If that goes well, they'll pair him with a solid defense to alleviate pressure on C.J. Stroud and a line that is still finding its footing.
Mac Jones (QB-SF) - Don't be surprised if Jones starts a lot more than two games. The 49ers gave an odd 2-5 weeks timeline for Brock Purdy's toe injury, which really sounds like "we'll see how Purdy feels in two weeks and go from there". A toe injury can easily be aggravated in the rigors of an NFL game, so don't be surprised if Purdy has more than one absence from this injury. Jones has been linked to Kyle Shanahan since the 49ers traded up to the #3 pick. If there's any truth to the rumor that Shanahan wanted him, here's the chance for them both to show what was possible if Kyle had his way. Right now, the 49ers offense is short-handed, but if Jones is piloting this group when it is healthier in the second half of the year, he could be a modest success. There's no reason to acquire Jones in 1QB leagues, but he could be a viable cheap answer to your QB2 spot in superflex leagues, and at least be useful depth in that format.