Week 4 Injuries, News, and Notes

Matchup previews for this week's NFL games, with all of the pertinent fantasy football news and notes.

Dave Kluge's Week 4 Injuries, News, and Notes Dave Kluge Published 09/26/2025

By Thursday afternoon, injury reports have usually told us most of the story. The final practice reports add the last details, but the week’s trends often give us a clear preview of what’s ahead in the coming weekend. Every Friday morning, Jeff Bell and Dave Kluge break down each matchup, highlighting the key injuries, depth chart shifts, and usage changes that matter for fantasy football. You can listen to the full podcast below for deeper analysis, or scroll through the matchup notes and bullet points for a quicker catch-up.

© Joe Rondone/The Republic / USA TODAY NETWORK via Imagn Images, week 4 injuries, fantasy football, footballguys,

Thursday Night Football - Thursday, 8:15 pm ET

Seattle Seahawks (3-1) @ Arizona Cardinals (2-2)

  • Seahawks beat the Cardinals 23-20

Sunday International Game - Sunday, 9:30 am ET

Minnesota Vikings (2-1) @ Pittsburgh Steelers (2-1)

Sunday Early Games - Sunday, 1:00 pm ET

Washington Commanders (2-1) @ Atlanta Falcons (1-2)

New Orleans Saints (0-3) @ Buffalo Bills (3-0)

  • Devaughn Vele (hip) LP
  • All fantasy-relevant Bills players are healthy

Cleveland Browns (1-2) @ Detroit Lions (2-1)

Tennessee Titans (0-3) @ Houston Texans (0-3)

  • Cam Ward (ankle/calf) LP Wednesday, FP Thursday
  • Nico Colins (knee) LP Wednesday, FP Thursday

Carolina Panthers (1-2) @ New England Patriots (1-2)

Los Angeles Chargers (3-0) @ New York Giants (0-3)

Philadelphia Eagles (3-0) @ Tampa Bay Buccaneers (3-0)

Sunday Afternoon Games - Sunday, 4:05 - 4:25 pm ET

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