Fantasy Matchups We Like in Week 2

Looking ahead to the games that fantasy managers can count on.

Bob Harris's Fantasy Matchups We Like in Week 2 Bob Harris Published 09/15/2026

IMAGN IMAGES via Reuters Connect Week 2 Matchups

Looking at the Week 2 schedule, what we learned in Week 1, likely game environments, and early market expectations, these are the five offensive matchups I like most for fantasy purposes.

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Buffalo Bills vs. Detroit Lions

This game's opening total sits at 51-to-53.5 points (depending on where you get your numbers), the highest of Week 2. Detroit allowed New Orleans 30 in Week 1, while Buffalo scored 36 on the Texans with Josh Allen delivering four touchdowns. That's an attractive setup for Allen and Buffalo's passing game, since Detroit's high-powered offense should keep the Bills aggressive for four quarters. DJ Moore and Dalton Kincaid, coming off big games in Houston, are must-starts. On the Detroit side, Jahmyr Gibbs, Amon-Ra St. Brown, Jameson Williams, Jared Goff, and Sam LaPorta are all solid; Gibbs and St. Brown are, of course, ceiling plays every week.

San Francisco 49ers vs. Miami Dolphins

Miami lost 27-13 in Las Vegas in Week 1 and now travels again to face a 49ers offense that just scored 27 on the Rams. San Francisco opens as a 10.5-to-13.5-point favorite, the largest spread of the week, with a 45.5-point over/under, a setup that points to fantasy success for Brock Purdy, Christian McCaffrey, Mike Evans, and George Kittle. Worth noting: McCaffrey's workload needs to normalize upward after a lighter-than-anticipated Week 1, and a blowout could cut passing volume late. Still, all four are potential ceiling plays.

Baltimore Ravens vs. New Orleans Saints

Baltimore just dropped 41 points on Indianapolis, with Derrick Henry rushing for 144 yards and scoring three times. Now the Ravens get a Saints defense that surrendered 31 points and 156 rushing yards to Gibbs in Detroit. Baltimore is an 8.5-point home favorite, but the total is a healthy 46.5-to-48. Lamar Jackson and Derrick Henry are obvious ceiling plays. Henry may be the player whose matchup I like most on the entire slate.

Washington Commanders at Dallas Cowboys

Looking for shootout potential? This one interests me more than the point spread might suggest because of the fantasy environment. The early total is around 49.5-to-51.5, second only to Lions-Bills. Dallas just allowed the Giants to score 28 points, and Washington is a more explosive unit. This is an especially appealing spot for Jayden Daniels, whose rushing ability gives him another avenue to exploit the Dallas defense much like Jaxson Dart did en route to a QB5 finish against the Cowboys last week.  

Philadelphia Eagles at Tennessee Titans 

We tend to chase defensive meltdowns, but Tennessee didn't collapse last week. They held the Jets to 23 points. Still, New York showed us how Philadelphia can attack the Titans. The Jets controlled possession for nearly 39 minutes, produced 367 yards, and Breece Hall ran for 102 yards. That sets Saquon Barkley and Jalen Hurts up for success. The lower game total keeps this below Baltimore and Washington for me, but the concentration of Philadelphia's fantasy production makes it attractive, especially for Barkley investors. If he can't hit the ceiling here, it might be time to worry.

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