Fantasy Matchups We Like in Week 3

Looking ahead to the games that fantasy managers can count on.

Bob Harris's Fantasy Matchups We Like in Week 3 Bob Harris Published 09/22/2026

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In Week 2, we liked the Buffalo-Detroit, San Francisco-Miami, Baltimore-New Orleans, Washington-Dallas, and Philadelphia-Tennessee. With all of them yielding at least 41 points, the five games averaged 52.4 total points (shout-out to the Bills-Lions for their 72-point output).

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Now, Week 3 is here, and we continue to get more data to work with. In this edition, I want to highlight matchups that give us both automatic starts capable of hitting their ceilings and players whose lineup value gets pushed upward based on the opponent. Here are the games that stand out to me this week.

Baltimore Ravens vs. Dallas Cowboys (in Rio de Janeiro, Brazil)

This is the obvious starting point. The 52.5-point total is Week 3's highest, and Dallas has allowed the fourth-most yards per game to opposing offenses. Lamar Jackson doesn't need matchup help, but this environment raises the ceiling for Rashod Bateman and Mark Andrews, particularly with Zay Flowers' improving-but-still-uncertain status. Dallas brings plenty to the other side. Dak Prescott threw four touchdowns against Washington Sunday, two to CeeDee Lamb, and Baltimore just allowed Tyler Shough to produce a strong fantasy outing. George Pickens remains a must-start play, and Jake Ferguson also belongs in the conversation.

San Francisco 49ers vs. Arizona Cardinals

Christian McCaffrey is already an automatic start; the matchup gives him a legitimate overall-RB1 ceiling. Arizona's defense has been better than expected over the first two games, but it remains in the middle of the pack overall. The Cardinals also have a long history of generosity to opposing tight ends (allowing the second-most fantasy points to the position last year). That's excellent news for George Kittle, while Brock Purdy and Deebo Samuel Sr. also deserve attention. The 49ers carry a 28-point implied total and are 8.5-point favorites, creating exactly the game script we'd want for McCaffrey. Don't dismiss Arizona, either: a trailing script could create volume for Trey McBride, Jeremiyah Love, and Michael Wilson.

Buffalo Bills vs. Los Angeles Chargers

Buffalo has scored 77 points through two games, including 41 against Detroit, and enters Week 3 with the slate's highest implied team total at 28.75 points. Josh Allen, James Cook III, and DJ Moore (if available) are lineup locks, but the environment makes Buffalo's secondary pieces more interesting. Dalton Kincaid, Khalil Shakir, and Keon Coleman can all benefit if this becomes the shootout suggested by the 50.5-point total. I'm more cautious with the Chargers because of their slow start, but the expected game script could generate enough volume to keep Justin HerbertOmarion Hampton, and Ladd McConkey viable. In deeper leagues, Oronde Gadsden II, Quentin Johnston, and Tre' Harris merit consideration.

Detroit Lions vs. New York Jets

Here's one where the matchup really helps around the edges of our lineups. Detroit is carrying a 27-point implied total and is favored by 6.5. That makes Jahmyr Gibbs the obvious centerpiece, but it also keeps Detroit's complementary players in our sights. Jared Goff, Amon-Ra St. Brown, Jameson Williams, and Sam LaPorta remain strong plays. While the Jets defense has capitalized on its early schedule -- New York has allowed the fewest yards per game this season -- Detroit's defense ranks 30th in yards per game allowed. Breece Hall and Garrett Wilson are locked-in starters. But don't overlook Adonai Mitchell. New York's WR2 drew 11 targets last week, giving him legitimate flex appeal against a Detroit defense that has struggled through two games. 

Kansas City Chiefs at Miami Dolphins

Kansas City carries a 28-point implied total, and Miami has allowed the seventh-most QB fantasy points. Even with the Chiefs favored by roughly 10.5 points, the matchup is excellent for Patrick Mahomes II and Ken Walker III -- although the anticipated game script favors Walker. One issue: beyond Travis Kelce and Rashee Rice, identifying which complementary Chiefs player benefits most could be trickier.

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